Best Heart Health Supplements: Top-Rated Cardiovascular Support Products

Heart disease is the leading cause of death worldwide. An estimated 32% of adults died from heart disease worldwide in 2019. 85% of these deaths were due to stroke and heart attack. More than 50% of deaths from heart disease occur in low- and middle-income countries.

An estimated 80% of heart disease may be preventable. Heart disease risk factors can be improved by a healthy diet, physical exercise, limiting alcohol intake, and avoiding smoke and tobacco. Suppose you can not incorporate all heart-healthy foods into your diet. You can take a heart health supplement to get cardioprotective nutrients like omega-3 fatty acids, folic acid, potassium, and fiber.

The Best Heart Health Supplements in 2022

Here are the best heart health supplements for cardiovascular support in 2022:

  • CardioFit MD
  • CellXRenewal
  • BioTrust OmegaKrill
  • Oweli Omega-3 Fish Oil
  • Primal Harvest Omega 3
  • Gundry MD Heart Defense
  • PhysioTru Physio Omega
  • Prociva
  • Blood Pressure 911
  • Genius Heart
  • Qunol Ultra CoQ10
  • Advanced Bionutritionals Advanced Blood Pressure Formula
  • Advanced CardioRX
  • PhytAge Labs Heart Beat 911
  • Amy Myers MD CardioGuard
  • BiOptimizers Magnesium Breakthrough
  • PureXanthin
  • Juvenon BloodFlow 7
  • Aqua Triplex
  • Cardio Clear 7

CardioFit MD


CardioFit MD by 1MD Nutrition is an all-in-one nutritional supplement supporting cardiovascular health. The sugar-free drink mix contains a carefully formulated blend of superfoods that fulfills all your dietary needs. It is packed with potent beetroot juice, Rhodiola root, bacillus coagulans, and a broad-spectrum fiber and prebiotics blend.

Each serving of CardioFit MD floods your body with optimal doses of essential vitamins and minerals that work in synergy with these superfoods to support all aspects of cardiovascular function, including oxygen transport, nourishment of body cells, waste metabolism, and coagulation after injury.

The flavorful drink mix is designed by Dr. Shenkman and the team at 1MD Nutrition. By taking one scoop of CardioFit MD in 355 ml of water, you can support your cardiovascular, circulatory, immune, and digestive health. The great-tasting drink mix also aids in weight loss and provides incredible stamina.

CardioFit MD is a keto-friendly, dairy-free, gluten-free, and sugar-free formula. It optimizes nitric oxide production, stimulates a neurotransmitter that promotes arterial function, normalizes blood pressure, and facilitates smooth oxygen and nutrient delivery, which are vital to a healthy cardiovascular system. One bag of 1MD Nutrition’s CardioFit MD costs $44.99.



Developed by Life Titan Naturals, CellXRenewal is a nutritional supplement that promotes cellular regeneration to improve metabolism and heart function. It is formulated to support your heart health, metabolism, cognition, and skin health.

The supplement contains a well-balanced blend of seven clinically studied ingredients to improve brain function, enhance skin appearance, boost energy levels, and support circulation. CellXRenewal supports your cardiovascular health by stimulating the production of hormones that influence the contraction and relaxation of artery walls. It also helps alleviate inflammation in the arteries and eliminate plaque to facilitate the smooth flow of blood.

The key ingredients present in the Life Titan Naturals’ CellXRenewal include brown seaweed, shilajit, marine phytoplankton, d-ribose, MSM, calcium-2 AEP, and vitamin D3, each of which has a specific role in supporting cardiovascular function and heart health. Priced at $69, one bottle of CellXRenewal comes with 60 vegan capsules.

BioTrust OmegaKrill


BioTrust OmegaKrill is a heart health supplement that contains three types of omega-3 fatty acids, namely eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA). The advanced supplement supports heart health, brain function, cognition, skin health, vision and eye health, immune function, and metabolism.

The supplement contains 100% pure, fresh, and clean oils and powerful antioxidants that support cell membranes in the brain, retinal, and heart tissues. BioTrust OmegaKrill is the only fish oil supplement with 1040 mg of docosahexaenoic acid (DHA). Each BioTrust OmegaKrill serving contains AstaReal, astaxanthin derived from Haematococcus Pluvialis algae extract proprietary blend.

OmegaKril is manufactured in compliance with the world’s most stringent standards for quality. It has also undergone third-party lab testing for its ingredients’ potency, purity, and freshness. You can enjoy superior cardiovascular support by taking three softgels of BioTrust OmegaKrill daily.

Priced at $49, one bottle of BioTrust OmegaKrill comes with 30 servings. A 60-day money-back guarantee also backs the gluten-free, soy-free, dairy-free, and non-GMO supplement.

Oweli Omega-3 Fish Oil


Oweli Omega-3 Fish Oil is an all-inclusive fish oil supplement with a powerful blend of essential omega-3 fatty acids. Each serving of Oweli Omega-3 Fish Oil comes with 576 mg of docosahexaenoic acid (DHA, 864 mg of eicosapentaenoic acid (EPA), and 2400 mg of fish oil.

Taking two softgels of Oweli Omega-3 Fish Oil daily can support your cardiovascular, bone, joint, immune, and skin health. The comprehensive formula present in Oweli’s Omega-3 Fish Oil provides metabolic support, aids in weight loss, slows age-related cognitive decline, fights age-related macular degeneration, supports positive mood, and boosts immune response, among tons of other benefits.

The supplement supports cardiovascular health by protecting arteries against inflammation, narrowing, stiffness, bulging, and plaque formation. It contains a highly absorbable formula that quickly gets into the bloodstream shortly after ingestion. Priced at $38.99, one bottle of Oweli’s Omega-3 Fish Oil comes with 30 servings.

Primal Harvest Omega 3


Primal Harvest Omega 3 is a premium-quality heart supplement formulated with 1,000 mg of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). These can reverse heart disease, reduce irregular heartbeats, and ease menstrual problems. It comes in the form of easy-to-swallow softgels free of unpleasant fish aftertaste.

The advanced supplement is made with sustainably harvested Norwegian fish, and its fish oil formula carries Friend of the Seaⓒ certification. Each Primal Harvest Omega 3 serving delivers 4 mg of vitamin E, 750 mg of marine lipid oil concentrate, 600 mg of eicosapentaenoic acid (EPA), and 400 mg of docosahexaenoic acid (DHA).

Taking two softgels of Primal Harvest Omega 3 can keep your heart functioning optimally and support your cognitive health. Like other fish oil supplements, Primal Harvest Omega 3 also optimizes inflammatory responses in bones, joints, and the body. The gluten-free, soy-free, and dairy-free supplement is manufactured in a GMP-certified facility in the United States and is backed by a 90-day money-back guarantee. Priced at $29.56, one bottle of Primal Harvest Omega 3 contains 60 softgels

Gundry MD Heart Defense


Gundry MD Heart Defense is a great-tasting supplement packed with energy-boosting, cardioprotective, and mood-enhancing ingredients. They support the proper functioning of your circulatory system, defend your body against oxidative damage, boost stamina, and alleviate depression.

Gundry MD Heart Defense comes with clinically effective coffee fruit extract, cocoa powder, flaxseed powder, prebiotic fiber, and essential mineral and vitamin doses. By taking one scoop of Gundry MD Heart Defense in water every day, you can enjoy dramatically increased energy, less stress, a healthy appetite, better digestion, and greater mental clarity.

You can expect to experience a robust surge in energy within an hour. However, you’ll have to wait two weeks to enjoy the appetite-suppressing benefits of the supplement. Only consistent use for over six months can ensure cardioprotective results.

The dark-chocolate-flavored supplement is manufactured in a GMP-certified facility in the United States. Priced at $42, one jar of Gundry MD Heart Defense comes with 30 servings. You can enjoy amazing discounts on ordering multi-jar packages. A 90-day money-back guarantee backs the supplement.

PhysioTru Physio Omega


PhysioTru Physio Omega is a comprehensive heart-protecting formula that reverses the damage of fatty diets you have been taking for years. It purportedly contains high-quality fish oil from sustainably caught Menhaden.

By taking two softgels of PhysioTru Physio Omega daily, you can support your heart health, avoid nasty mental conditions, and enjoy clearer vision, better skin appearance, and more incredible energy.

The supplement promotes healthy cardiovascular function by improving cholesterol levels, reducing blood pressure, decreasing triglyceride levels, and preventing plaque formation. One bottle of PhysioTru Physio Omega contains 60 softgels and costs $67.



Prociva by Simple Promise is a heart health supplement filled with a potent blend of herbal superfoods and vitamins that work synergistically to prevent myocardial damage and preserve the heart. Single Promise’s Prociva benefits include improved blood pressure, cellular support for the heart muscle, healthy heart rhythm, reduced body fat levels, and healthy vascular function.

Each serving of Single Promise’s Prociva comes with potent doses of motherwort, arjuna, folic acid, vitamin D, and magnesium, all of which have been proven to support heart function.

Prociva is manufactured in a GMP-certified facility in the United States and has undergone rigorous third-party lab testing for its safety, quality, and effectiveness. Priced at $49, one bottle of Prociva contains 60 capsules that constitute a month’s supply.

Blood Pressure 911


Developed by Phytage, Blood Pressure 911 is a premium blood pressure support supplement containing a precise combination of essential vitamins that fulfill your dietary requirements to enable the proper functioning of your cardiovascular system.

With regular use of Blood Pressure 911, you can experience positive improvements in your cholesterol levels, stamina, blood pressure, blood glucose, and heart rhythm. Manufactured in a GMP-certified facility in the United States, Blood Pressure 911 has helped thousands of people maintain healthy blood pressure levels.

From transport of oxygen to delivery of nutrients to cells to waste metabolism, Blood Pressure 911 is designed to support your cardiovascular function. It is a 100% natural formula distilled to the highest possible purity. One bottle of Blood Pressure 911 costs $69.95 and contains 60 capsules. All Blood Pressure 911 purchases come with free shipping and a 90-day money-back guarantee.

Genius Heart


Genius Heart is an all-natural heart health supplement designed to help men and women enjoy a healthy lifestyle. Whether you want to control your blood pressure levels or have greater anaerobic endurance, you can rely on Genius Heart to optimize your overall health.

Each serving of Genius Heart is infused with 600 mg of pantethine, 300 mg of BP grape seed extract, 100 mg of coQ10, and 60mcg of vitamin K, all of which are present in the form of premium-quality proprietary blends.

Genius Heart supports healthy blood pressure by promoting pliable, open blood vessels and protecting the arteries against plaque formation, narrowing, bulging, and stiffening. Regular use of Genius Heart over a prolonged period can guard against hypertension. The supplement costs $44.99 per bottle and comes with 60 veggie capsules that constitute 30 servings.

Qunol Ultra CoQ10


Qunol Ultra CoQ10 is a cardiologist-recommended dietary supplement with clinically effective doses of vitamin E and coenzyme Q10, a powerful antioxidant that your body cells need for growth and maintenance. The supplement is three times more absorbable than regular Co10Q.

By taking Qunol Ultra CoQ10 daily, you can supply a potent concentration of CoQ10 to your heart and maintain your blood pressure within a normal range. You can simply take one softgel of Qunol Ultra CoQ10 with food every day to provide your heart with the highest quality support. One bottle of Qunol Ultra CoQ10 costs $23.80 and contains 60 softgels.

Advanced Bionutritionals Advanced Blood Pressure Formula


Advanced Blood Pressure Formula by Advanced Bionutritionals is a carefully formulated supplement containing a unique blend of herbs that have been used in traditional medicine to promote healthy blood pressure, blood sugar levels, and triglyceride levels.

Each serving of Advanced Blood Pressure Formula contains extracts of Chinese salvia root, rhizome tree peony root bark, gardenia fruit, Chinese skullcap root, anemarrhena, rhizome pearl shell, scabrous gentian root, rhizome Rehmannia root, tuber achyranthes root, prunella Vulgaris fruit, and chrysanthemum flower along with 50 mg of elemental magnesium and hibiscus.

Regular use of Advanced Blood Pressure Formula for several months or as recommended by your physician can help you avoid cardiovascular issues including arrhythmia, heart attack, heart muscle disease, pulmonary embolism, deep vein thrombosis, and narrowing of the arteries. One Advanced Blood Pressure Formula bottle by Advanced Bionutritionals comes with 60 capsules for $29.95.

Advanced CardioRX


Advanced CardioRX is a fish oil supplement containing a 100% natural blend of clinically studied ingredients, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). It is an all-in-one formula that supports cardiovascular health, including triglyceride levels, arterial function, blood pressure, and blood glucose levels.

If you want to enjoy all the fantastic health benefits of fish oil without its unpleasant taste, you should start taking two capsules of Advanced CardioRX daily. With regular use of Advanced CardioRX, you can minimize the risk of heart problems while enjoying enhanced energy levels. One bottle of Advanced CardioRX is priced at $69.

PhytAge Labs Heart Beat 911


Heart Beat 911 by PhytAge Labs is an advanced cardiovascular protection formula containing premium-quality fish oils. It is a 100% natural, cruelty-free, a non-GMO supplement that floods your body with optimal omega-3 fatty acids doses.

The supplement supports your heart health by optimizing blood pressure levels, promoting healthy blood flow, lowering triglyceride levels, maintaining healthy cholesterol levels, and providing structural and functional support to your heart muscle.

PhytAge Labs’ Heart Beat 911 can also be taken by people who have undergone heart surgery to prevent the adverse effects of a heart attack. You can get one bottle of Heart Beat 911 for $69.95. Each bottle comes with Heart Beat 911 30 soft gelatin capsules.

Amy Myers MD CardioGuard


CardioGuard is a highly bioavailable heart-supporting formula created by Amy Myers, MD. It contains a unique combination of n-acetyl l-carnitine, coenzyme Q10, and a novel prebiotic called l. reuteri NCIMB 30242. You also get 2.6 mg of vitamin B2, 10 mg of vitamin B6, and 20 mg of magnesium with each serving of CardioGuard.

Each ingredient present in CardioGuard performs a specific role in supporting your cardiovascular health. CoQ10 alleviates oxidative damage in the arteries and throughout the body. L. reuteri NCIMB 30242 optimizes the levels of high-density lipoproteins and low-density lipoproteins.

Magnesium dilates the blood vessels to enable smooth blood flow and healthy blood pressure. N-acetyl l-carnitine boosts mitochondrial energy metabolism, and B vitamins facilitate energy production while enhancing the bioavailability of the entire formula.

CardioGuard is an excellent choice for people affected by hormonal imbalances, autoimmune problems, and cardiovascular issues like high cholesterol, hypertension, or arrhythmia. The gluten-free, dairy-free, and soy-free supplement has undergone third-party lab testing for its safety, purity, and quality. Priced at $59.97, one bottle of CardioGuard contains 60 capsules that constitute 30 servings.

BiOptimizers Magnesium Breakthrough


Magnesium Breakthrough by BiOptimizers is a well-designed nutritional formula that helps reduce stress levels, boosts immune function, maintains normal heart rhythm, supports bone strength, and encourages sleep. The unique supplement contains many different types of magnesium, including magnesium chelate, magnesium citrate, magnesium bis-glycinate, magnesium malate, magnesium sucrosomial, magnesium taurate, and magnesium orotate.

These magnesium types work together to promote muscle building, improve vascular function, support digestion, relieve pain, boost energy production, and enhance physical performance, among other benefits.

If you do not want to rely on exotic herbs or natural superfoods to support your cardiovascular health, you can use BiOptimizers Magnesium Breakthrough to enjoy similar benefits. It is packed with essential nutrients that you consume every day through diet. With all seven significant forms of magnesium, BiOptimizers Magnesium Breakthrough is one of the best magnesium supplements. It is manufactured in a cGMP facility in the United States. One bottle of BiOptimizers Magnesium Breakthrough is priced at $35.



PureXanthin is a high-quality nutritional supplement designed by Kriss Berg, a certified nutritionist, and researcher at The Healthy Living Association. With an optimal dose of astaxanthin, PureXanthin lowers high blood pressures and improves elastin levels in your artery walls, preventing arteries’ thinning.

By taking two capsules of PureXanthin daily, you can enjoy improved heart health, relief from joint pain, smoother skin appearance, better mood, healthy weight, and more incredible stamina. Priced at $59, one bottle of PureXanthin comes with 60 soft gelatin capsules.

Juvenon BloodFlow 7


Juvenon BloodFlow 7 is a powerful supplement designed to improve vascularity, boost blood flow, maximize muscle gains during workouts, enhance brain performance, and increase energy levels. The supplement features potent doses of l-arginine, l-citrulline, green coffee bean extract, turmeric root extract, green tea leaf extract, tart cherry extract, kale, broccoli, and blueberry extract.

It is a nitric oxide booster that supports healthy aging, cardiovascular health, and physical performance. It contains two non-essential amino acids that optimize circulation, maintain healthy organs, and promote healthy blood pressure. By taking three capsules of Juvenon BloodFlow 7 daily, you can maintain a healthy vascular function and optimal heart health. One Juvenon BloodFlow 7 bottle comes with 90 pills for $39.95.

Aqua Triplex


Aqua Triplex is an ocean-based dietary supplement that supports healthy blood pressure and a robust cardiovascular system. It is packed with three clinically studied ingredients: antioxidant, anti-inflammatory, anti-obesity, antitumor, cardio-protective, and liver-protective properties.

If you are looking for a natural way to maintain healthy blood pressure, Aqua Triplex can help. It contains a perfectly designed combination of calamari, cholecalciferol, and brown seaweed extract, each offering cardiovascular support.

Regular use of Aqua Triplex for over six months can help reverse the damage to the cardiovascular system caused by a fatty diet and diseases like atherosclerosis, hypertension, and type 2 diabetes. One bottle of Aqua Triplex costs $49 and comes with 60 capsules.

Cardio Clear 7


Cardio Clear 7 is a meticulously formulated nutritional supplement that provides all-inclusive cardiovascular support. The cutting-edge formula is packed with safe, well-researched, clinically studied ingredients that exhibit cardioprotective effects.

Each Cardio Clear 7 serving comes with optimal coenzyme Q10, shilajit, and pyrroloquinoline quinone doses. You can easily incorporate Cardio Clear 7 into your daily routine. According to the maker, regular supplement intake for over five months can help optimize heart functioning, maintain blood pressure within normal ranges, and achieve a healthy balance between good and bad cholesterol.

One Cardio Clear 7 bottle comes with 30 vegan capsules for $49.95. A 365-day money-back guarantee backs the supplement.

The Best Heart Health Supplements Ranking Criteria

All heart health supplements are marketed to support your cardiovascular health and minimize the risk of heart disease. However, not all supplements are effective at optimizing cardiovascular function. We used several metrics to differentiate the best heart health supplements from the worst. Below are the factors we took into consideration while preparing the list:


Many heart health supplements contain too many ingredients that have not been proven to support heart health. While preparing the list, we preferred supplements that contain 100% natural, safe, well-researched, and clinically studied ingredients that have been proven to optimize the cardiovascular system. We were wary of supplements packed with fillers, artificial chemicals, and components backed by junk science.

Additionally, we also considered the source of each ingredient present in supplements. All supplements mentioned above contain ingredients sourced from clinically monitored farms. We were careful of supplements that contained low-quality ingredients obtained from low-quality sources.


For a formula to be effective, it must contain the right amount of suitable ingredients. Some heart health supplements contain shallow doses of cardioprotective ingredients, which render them completely ineffective. Similarly, some supplements contain incredibly high components that may cause serious side effects. All supplements listed above contain the right amount of each ingredient as determined by double-blind, placebo-controlled clinical trials.

Brand Credibility and Reputation

With so many companies selling heart health supplements, it is difficult to determine the best. The manufacturer’s reputation goes a long way in determining the quality of their product.

Our list comprehends products offered by highly credible manufacturers with a flawless track record of selling high-quality supplements. However, we were in no way biased against newly launched companies. Its reputation was not merely determined by its history of serving the health and wellness industry. Our team considered various factors to determine the brand’s credibility, including customer reviews, doctor’s recommendations, certification, manufacturing standards, and third-party lab testing.

Formula Development

While cardiologists formulate some supplements, some are designed by marketing teams without consulting professionals. Heart health supplements developed by marketing teams under the supervision of a certified professional can be effective. However, it’s better to choose a doctor-formulated supplement. Almost all products listed above have been designed under the supervision of a medical advisory board. We preferred supplements developed by medical doctors (MDs), cardiologists, and registered dietitians (RDs).

Advertised Benefits

Many companies tend to mislead customers by making overly exaggerated claims about their products, such as 100% protection against heart disease, instant reduction in blood pressure in hypertensive patients, and lowering the body’s production of triglycerides overnight.

We were cautious of brands that make these delusive claims about their products. All heart health supplements come from reputable health and wellness brands that run direct marketing campaigns. The advertised benefits of these supplements may not look impressive because they have been advertised honestly.

Price & Value

While some people want to spend a hundred dollars a month on heart health supplements, some do not have the budget to do so. Whether you are working on a budget or have plenty of money to spend, our list comprehends a variety of products belonging to different price ranges. You’ll get excellent results if you opt for an expensive supplement. However, you won’t have to compromise on quality if you choose the least costly supplement. We focused on good value at all price points.

Satisfaction or Money-back Guarantee

Our list includes different heart supplements that uniquely optimize your cardiovascular function. While some use omega-3 fatty acids to support your heart health, some contain cardio-protective herbal ingredients. A supplement primarily designed to help healthy blood pressure may not effectively control blood glucose levels.

A money-back guarantee can save you a lot of money if a supplement does not work. All heart health supplements on our list are backed by a money-back or satisfaction guarantee.

Scientific Evidence For Heart Health Supplements

Many heart health supplements have not completed well-designed clinical trials. However, the ingredients present in the supplements above have undergone individual, third-party clinical trials for their heart-supporting and cardioprotective effects.


According to researchers, CoQ10 may reduce the risk of repeat heart attacks and improve outcomes in patients with heart failure. Researchers also report that CoQ10 may also provide significant benefits for hypertension and prevent the adverse effects of cholesterol-lowering statins.

A recent study was published in Cardiovascular Pharmacology. The findings show that CoQ10 does not exhibit significant cardioprotective effects that could minimize potentially life-threatening cardiovascular diseases, such as heart attack, heart failure, stroke, sudden cardiac arrest, peripheral artery disease, and aneurysm.

In a clinical study involving 420 people with heart failure, a two-year treatment with CoQ10 improved subjects’ symptoms and decreased the risk of heart problems resulting in death. In another study of 641 people, they were treated with CoQ10 or a placebo for a year. At the end of the study, subjects treated with CoQ10 had fewer serious heart failure complications and were hospitalized less frequently.

Researchers concluded that CoQ10 could help optimize energy production, alleviate oxidative damage, and improve cardiovascular function, which positively impacts the treatment of heart failure.

Omega-3 Fatty Acids

Omega-3 fatty acids are also present in a wide range of heart health supplements. The most compelling evidence for the cardioprotective effects of omega-3 fatty acids comes from three large controlled trials of 32,000 participants supplemented with docosahexaenoic acid (DHA) eicosapentaenoic acid (EPA) or to act as controls. According to these trials, omega-3 fatty acids can reduce cardiovascular events by 19% to 45%.

Researchers concluded that docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), whether from nutritional supplements or food, should be increased in people with or at risk for coronary artery disease. They also concluded that docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are about one g/d for people with known coronary artery disease and 500 mg/d for those without the disease.

The findings also show that 3 to 4 g/d of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) can lower triglyceride levels by 20% to 50%. Though consuming oily fish twice a week can provide 400 to 500 mg/d of DHA and EPA, patients with hypertriglyceridemia must use a supplemental form of fish oil if they live a sedentary lifestyle or are affected by uncontrolled diabetes mellitus and obesity.

Most studies on omega-3 fatty acids or fish oil test docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) concurrently. According to some individual clinical studies of docosahexaenoic acid (DHA), DHA may improve several markers of heart health more effectively than EPA.

One study involving 154 obese individuals shows that regular supplementation of DHA for more than two months can significantly increase the omega-3 index, a blood marker of omega-3 levels associated with a reduced risk of sudden death related to heart disease. In this study, subjects were given daily doses of 2,700 mg of DHA for ten weeks, and their omega-3 index increased by 5.6%. When the subjects were given the same amount of eicosapentaenoic acid (EPA), they had only a 3.3% increase in the omega-3 index. In another study, subjects were given the same docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) doses. DHA lowered blood triglyceride levels by 13.3%, compared to 11.9% by EPA. DHA also increased the levels of high-density lipoprotein more than EPA – 7.6% versus a slight decrease for EPA.

Docosahexaenoic acid (DHA) also increases bad cholesterol or low-density lipoproteins. However, large, fluffy, low-density lipoprotein particles are not linked to increased heart disease risk like small, dense LDL particles. DHA also enables smooth blood flow and supports circulation, and may even enhance the ability of your blood vessels to dilate, minimizing the risk of coronary artery disease.

A review of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in 20 clinical studies found they may cause a notable reduction in blood pressure. However, each fatty acid may affect different aspects of vascular function to lower blood pressure. Researchers concluded that DHA lowered the diastolic blood pressure by 3.1 mmHg, and the EPA lowered systolic blood pressure by 3.8 mmHg.

As elevated systolic blood pressure is a more significant risk factor for heart disease than diastolic blood pressure for adults over the age of 50, EPA may be more effective at minimizing the risk of heart disease in the elderly. However, elevated diastolic blood pressure also increases the risk of heart attack and stroke.


Many clinical studies suggest that astaxanthin may slightly improve several markers of vascular diseases, including hypertension, aneurysm, stroke, coronary artery disease, and peripheral artery disease (PAD).

According to a rat-based study conducted in 2006, astaxanthin may improve elastin levels and arterial wall thickness. Some animal studies also suggest that astaxanthin may help reduce low-density lipoprotein levels and improve several markers of heart disease. However, the findings are not supported by adequate evidence.

Some astaxanthin derivatives have been documented to have cardioprotective properties after oral and intravenous administration in several animal species. The keto-carotenoid alleviates oxidative stress and inflammation, contributing to atherosclerotic cardiovascular disease pathophysiology. Whether astaxanthin exhibits primary or secondary therapeutic effects in humans’ atherosclerotic cardiovascular disease is unknown.

A study on the working mechanism of astaxanthin shows that the chemical powerfully quenches singlet oxygen from reactive oxygen species to reduce oxidative stress. The study suggests that astaxanthin may be more effective at attenuating cardiovascular disease than vitamin E, vitamin C, beta carotene, and other previously investigated carotenoids.

Frequently Asked Questions About Heart Health Supplements

We get zillions of questions about heart health supplements every day. Here are some of the commonly asked questions about heart health supplements and how they work:

Q: How is cholesterol linked to cardiovascular disease?

A: Cholesterol is a class of organic molecules your body needs to build healthy cells. However, high levels of these organic molecules can increase the risk of cardiovascular disease. Fatty deposits develop in your blood vessels when you have high cholesterol levels. As these deposits build up, they block the arteries and impair the smooth flow of blood, causing atherosclerosis.

Q: What are the symptoms of high cholesterol?

A: The most common symptoms of high cholesterol are chest pain, nausea, extreme fatigue, shortness of breath, numbness or coldness in extremities, and pain in the jaw, back, neck, and upper abdomen.

Q: Are cardiovascular problems more common in men compared to women?

A: Yes, cardiovascular problems are usually higher in men than women. However, women typically have a worse prognosis after acute cardiovascular events.

Q: Can young people be hypertensive?

A: Yes, children between 12 and 19 can have hypertension. Hypertension is more common in obese children.

Q: What are the early symptoms of a heart attack?

A: The early symptoms include chest pain, lightheadedness, shortness of breath, and pain or discomfort in the extremities, jaw, neck, and back.

Q: What are the risk factors for cardiovascular disease?

A: The risk factors for cardiovascular disease include genetics, age, sex, tobacco, fatty diet, physical inactivity, and alcohol.

Q: Do older people have a higher risk of heart disease?

A: Yes, adults aged 65 and older are more likely to be affected by cardiovascular disease than younger adults. Aging can cause changes in the cardiovascular system that may increase the risk of cardiovascular disease.

Q: Does lowering the intake of saturated fat help improve heart health?

A: Yes, lowering saturated fat intake and replacing it with mono and polyunsaturated fats can help reduce low-density lipoproteins in your blood and improve your heart health.

Q: Are fish oil supplements good for cholesterol?

A: Fish oil supplements contain omega-3 fatty acids that lower blood triglyceride levels. Omega-3 fatty acids also increase ‘good’ and ‘bad’ cholesterol. However, they only increase the number of large, fluffy particles of LDL or ‘bad’ cholesterol, which are not associated with cardiovascular disease.

Q: Is exercise good for arrhythmia?

A: Yes, exercise can help control arrhythmia or irregular heartbeat.

Q: Does exercise improve cardiovascular health?

A: Yes, physical exercise improves cardiovascular health through adaptations to your heart and vascular system. Regular exercise helps reduce blood pressure, decrease resting heart rate, increase physiological cardiac hypertrophy, and optimize lipoprotein levels in the blood.

Q: How many hours should I exercise a week to support my cardiovascular health?

A: You should engage in at least two and a half hours of moderate aerobic activity or one hour of vigorous aerobic exercise per week.

Q: Is heart disease genetic?

A: Yes, heart conditions can be genetic. Both men and women are equally vulnerable to genetic heart disease. Coronary artery disease is a congenital cardiovascular disease that leads to stroke, heart failure, and heart attack. The risk for heart disease is also influenced by genetics in many ways.

A: What are the best foods for good heart health?

The best foods for a healthy heart include oats and barley, fatty fish like salmon, dark leafy greens, beets, nuts and seeds, legumes, low-fat dairy, and olive oil.


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